Veterinary OTC

[Veterinary Drug Name]

Generic name: Oxfendazole Granules

Trade name: Luofen

English name:Oxfendazole Granules

Pinyin: Aofendazuo Keli

[Main Ingredients] Oxfendazole

[Description] This drug is of off-white granules.

[Pharmacological Action] Antihelmintic. Oxfendazole possesses a wide range of anthelmintic activity targeting nematodes, tapeworms, and trematodes, but it does not work against schistosomes. Its mode of action involves binding to the tubulin proteins of susceptible parasites, inhibiting their ability to polymerize with α-tubulin and form microtubules, which in turn impacts the worms' cellular processes such as mitosis, protein assembly, and energy metabolism that are essential for their reproduction. Oxfendazole is readily absorbed from the gastrointestinal tract. The drug has an elimination half-life of about 7.5 hours in sheep and 2.5 hours in goats. Post-absorption, oxfendazole is converted into its active metabolite, fenbendazole sulfone.

[Function and Use] Antihelmintic, for the treatment of nematodosis and tapeworm disease of livestock.

[Dosage and Administration] On the basis of this drug. Oral administration: 100mg/time per 1kg of body weight for horses; 50mg/time per 1kg of body weight for cattle; 50 - 75mg/time per 1kg of body weight for sheep; 40mg/time per 1kg of body weight for pigs; 100mg/time per 1kg of body weight for dogs.

[Adverse Reaction] Having embryotoxicity and teratogenic actions.

[Precautions] (1) It is prohibited during lactation period.

        (2) Use of this drug should be approached with caution in animals that are in the early stages of pregnancy.

        (3) Resistance to this drug may emerge in sensitive parasites, potentially leading to cross-resistance with other benzimidazoles.

        [Withdrawal Period] 7 days for horses, cattle, sheep, and pigs.

        [Specification] 10%

        [Package] 1000g/bag × 20bags/carton

        [Storage] It should be kept out of light and tightly sealed in dry place.

        [Shelf Life] 2 years

        [Production License No.] (2022) SYSCZZ No. 08019

        [GMP Certificate No.] (2022) SY GMP ZZ No. 08010

        [Approval No.] SYZ No. 080196247

        [Executive Standard] Chemical Drug Volume of Veterinary Drug Quality Standard (2017 Edition)