Veterinary OTC
[Veterinary Drug Name]
Generic name: Furosemide Injection
Trade name: Shuizhongan
English name: Furosemide Injection
Pinyin: Fusaimi Zhusheye
[Main Ingredients] Furosemide
[Description] This drug is of colorless or almost colorless transparent liquid.
[Pharmacological Action] Furosemide predominantly targets the medullary segment of the loop of Henle, suppressing the renal tubule's reabsorption of Cl⁻ and Na⁺, with an additional impact on the cortical segment of the ascending limb. This leads to elevated Na⁺ and Cl⁻ levels in the lumen fluid and a reduction in Na⁺ and Cl⁻ concentrations within the medullary interstitial fluid, diminishing the tubule's capacity to concentrate and resulting in increased excretion of water, Na⁺, and Cl⁻. The diminished reabsorption of Na⁺ raises its concentration in the distal tubule, which in turn boosts the exchange of Na⁺_K⁺ and Na⁺_H⁺, augmenting the excretion of K⁺ and H⁺. Furthermore, Furosemide inhibits the reabsorption of Na⁺ and Cl⁻ in both the proximal and distal convoluted tubules, intensifying the Na⁺_K⁺ exchange in the distal tubule and facilitating K⁺ excretion.
[Drug Interaction] (1) The simultaneous use of aminoglycoside antibiotics may amplify their potential to cause kidney and ear damage.
(2) Furosemide is able to boost the efficacy of succinylcholine.
(3) Glucocorticoid drugs might reduce the diuretic effect and increase the risk of electrolyte disorders, especially hypokalemia, which could lead to an increase in digitalis toxicity.
(4) This substance can vie with aspirin for the renal clearance pathways, thus prolonging its effectiveness.
(5) Theophylline, when co-administered, can strengthen the diuretic activity.
[Function and Use] Diuretic drug, for the treatment of a range of edema cases.
[Dosage and Administration] Intramuscular or intravenous injection: 0.05-0.1ml/time per 1kg of body weight for horses, cattle, sheep, and pigs; 0.1-0.5ml/time per 1kg of body weight for dogs and cats.
[Adverse Reaction] (1) It can lead to imbalances in electrolytes like hyponatremia, hypokalemia, hypocalcemia, and hypomagnesemia, and dehydration can often result in azotemia.
(2) High-dose intravenous administration may lead to auditory loss in dogs.
(3) It can also lead to conditions such as gastrointestinal disturbances, anemia, leukopenia, and weakness.
[Precautions] (1) It is contraindicated for animals without urine output, and caution is advised for those with electrolyte disorders or hepatic impairment.
(2) Long-term, high-dose treatment may lead to hypokalemia, hyponatremia, hypocalcemia, hypomagnesemia, and dehydration, which requires the combined or sequential use of potassium supplements or potassium-sparing diuretics, along with regular checks on hydration and electrolyte levels.
(3) Avoidance of combination with aminoglycoside antibiotics and glucocorticoids is advised.
[Withdrawal Period] It is not required.
[Specification] 10ml: 100mg
[Package] 10ml/pc × 10 pcs/box × 40 boxes/carton
[Storage] It should be kept out of light and tightly sealed for storage.
[Shelf Life] 2 years
[Production License No.] (2022) SYSCZZ No. 08019
[GMP Certificate No.] (2022) SY GMP ZZ No. 08010
[Approval No.] SYZ No. 080191182
[Executive Standard] Volume I of Veterinary Pharmacopoeia of the People’s Republic of China (2020 Edition)
