Veterinary Rx

[Veterinary Drug Name]

Generic name: Pralidoxime Iodide Injection

Trade name: Jieduke

English name: Pralidoxime Iodide Injection

Pinyin: Dianjielinding Zhusheye

[Main Ingredients] Pralidoxime iodide

[Description] This drug is of colorless or almost colorless transparent liquid.

[Pharmacological Action] This drug directly binds to the phosphorylated group of cholinesterase through its quaternary ammonium group, and then detaches from cholinesterase, allowing the enzyme to regain its activity. Cholinesterase inhibited by organophosphorus for over 36 hours has difficulty restoring its activity. Therefore, at the time of using cholinesterase reactivators to treat organophosphorus poisoning, early administration is more effective, while it is ineffective in treating chronic organophosphorus poisoning. Oxime compounds can also directly bind with organophosphorus in the blood, transforming them into non-toxic substances that are excreted in urine. Pralidoxime iodide can be used to treat various organophosphorus poisonings, but its detoxifying effect on organophosphorus compounds is limited. It is more effective against poisoning by compounds such as systox and parathion, but less effective for poisonings caused by malathion, dichlorvos, and dipterex. It is ineffective against carbamate pesticide poisoning.

For mild organophosphorus poisoning, this drug or atropine can be used alone to control the poisoning symptoms. In moderate or severe poisoning, because this drug has no effect on the acetylcholine already accumulated in the body, atropine must be used in combination. As atropine can alleviate the symptoms of organophosphorus poisoning, its combination with cholinesterase reactivators in cases of severe poisoning has a synergistic action. Therefore, at the time of treating organophosphorus poisoning clinically, atropine must be administered promptly and in sufficient amounts.

[Drug Interaction] (1) This drug has a synergistic action on controlling organophosphorus poisoning when it is used with atropine. (2) It is easy to decompose with alkaline drugs, reducing the drug efficacy.

[Function and Use] Antidote, for organophosphorus poisoning. It can activate inhibited cholinesterase.

[Dosage and Administration] Intravenous injection: 0.6-1.2ml/time per 1 kg of body weight for livestock.

[Adverse Reaction] Rapid injection of this drug can cause vomiting, rapid heart rate and ataxia. Blood pressure fluctuations and respiratory depression can also be caused by large doses and fast injection speed.

[Precautions] (1) It is strictly prohibited to use this drug with alkaline drugs

(2) Animals poisoned with organophosphorus by internal administration should be given a thorough gastric lavage with 2.5% sodium bicarbonate solution (except dipterex). Since the back of the digestive tract can also absorb organophosphorus, the application of this product should be maintained for at least 48 to 72 hours to prevent the delayed absorption of organophosphorus from aggravating the degree of toxicity, or even death.

(3) Blood cholinesterase levels should be measured regularly during administration as a monitoring index for medicine administration. Blood cholinesterase should be maintained above 50%-60%. This drug can be used repeatedly when necessary.

(4) This drug has a synergistic action with atropine. Therefore, the dose of atropine can be reduced appropriately, when they are combined.

[Withdrawal Period] It is not required.

[Specification] 10ml: 0.25g

[Package] 10ml/pc × 10 pcs/box × 40 boxes/carton

[Storage] It should be kept out of light and tightly sealed for storage.

[Shelf Life] 2 years

[Production License No.] (2022) SYSCZZ No. 08019

[GMP Certificate No.] (2022) SY GMP ZZ No. 08010

[Approval No.] SYZ No. 080191668

[Executive Standard] Volume I of Veterinary Pharmacopoeia of the People’s Republic of China (2020 Edition)