Veterinary OTC

[Veterinary Drug Name]

Generic name: Sulfamonomethoxine Sodium Injection

Trade name:

English name: Sulfamonomethoxine Sodium Injection

Pinyin: Huang’an Jianjiayangmidingna Zhusheye

[Main Ingredients] Sulfamonomethoxine Sodium

[Description] This drug is of colorless to light yellow transparent liquid.

[Pharmacological Action] This drug is a broad-spectrum antimicrobial drug and has the strongest antibacterial activity both in vivo and in vitro among sulfonamides. It not only has a strong inhibitory effect on most Gram-positive and negative bacteria, and bacteria develop resistance to this drug slowly, but also has good antibacterial effects against Gram-positive and negative bacteria such as pyogenic streptococci, Salmonella, and Klebsiella pneumoniae. Besides, sulfonamides are structurally similar to para-aminobenzoic acid and compete with it for bacterial dihydrofolate synthetase, so as to hinder the synthesis of dihydrofolic acid and ultimately affect nucleic acid synthesis as well as inhibit bacterial growth and reproduction. The action of sulfonamides can be antagonized by para-aminobenzoic acid and its derivatives (procaine, tetracaine). In addition, pus and tissue breakdown products can also provide essential substances for bacterial growth, and produce an antagonistic effect with sulfonamides.

[Drug Interaction] (1) When used in combination with trimethoprim (an antimicrobial synergist), it can produce a synergistic effect.

(2) Some drugs containing a para-aminobenzoyl group, such as procaine and tetracaine, can generate para-aminobenzoic acid in the body. Yeast tablets also contain para-aminobenzoic acid required for bacterial metabolism; concurrent use can reduce the effectiveness of this drug.

(3) Concurrent use with thiazide or loop diuretics like furosemide can exacerbate renal toxicity.

[Function and Use] Sulfonamide antimicrobial drug, for the treatment of infections caused by susceptible bacteria and can also be used for infections such as Toxoplasma gondii in swine.

[Dosage and Administration] Intravenous injection: 0.17ml/time per 1kg of body weight for livestock. Once or twice a day, administered for 2-3 consecutive days.

[Adverse Reaction] (1) Sulfonamides or their metabolites can precipitate in the urine, and crystalluria is more likely to occur with high-dose administration or long-term low-dose use, as well as lead to crystalline urine, hematuria, or renal tubular obstruction.

(2) Intravenous injection in horses may cause temporary paralysis.

(3) The sulfonamide injection solution is a strongly alkaline solution and has a strong irritant effect on tissues.

[Precautions] (1) This drug may precipitate crystals when in contact with acids, therefore it should not be diluted with 5% glucose solution.

(2) Long-term or high-dose use can easily cause crystalluria; sodium bicarbonate should be used simultaneously, and the affected animal should be given plenty of water to drink.

(3) If an allergic reaction or other serious adverse reactions occur, it is needed to stop the medication immediately and provide symptomatic treatment.

[Withdrawal Period] 28 days for livestock; 7 days for the weaning period

[Specification] 10ml: 3g

[Package] 10ml/pc × 10 pcs/box × 40 boxes/carton

[Storage] It should be kept out of light and tightly sealed for storage.

[Shelf Life] 2 years

[Production License No.] (2022) SYSCZZ No. 08019

[GMP Certificate No.] (2022) SY GMP ZZ No. 08010

[Approval No.] SYZ No. 080192574

[Executive Standard] Volume I of Veterinary Pharmacopoeia of the People’s Republic of China (2020 Edition)