Veterinary OTC

[Veterinary Drug Name]

Generic name: Flunixin Meglumine Injection

Trade name: Shumeida

English name: Flunixin Meglumine Injection

Pinyin: Funixin Pujia’an Zhusheye

[Main Ingredients] Flunixin Meglumine

[Description] This drug is of colorless or light yellow transparent liquid.

[Pharmacological Action] Pharmacodynamics: As a potent cyclooxygenase inhibitor, flunixin meglumine has analgesic, antipyretic, anti-inflammatory, and anti-rheumatic effects. The analgesic effect refers to blocking the transmission of pain impulses by the inhibition of the synthesis of peripheral prostaglandins or their pain sensitizers, or their combined action. The anti-inflammatory effect of peripheral tissues may be caused by inhibiting cyclooxygenase, reducing the formation of prostaglandin precursors, and inhibiting other mediators to induce local inflammatory responses.

Pharmacokinetics: After a single intramuscular injection in pigs (2.2mg/kg body weight), the half-life of plasma elimination is 3-4 hours, and the peak concentration is 2.94μg/ml, with a peak time of 0.4 hours. The drug can still be detected in the blood 18 hours after administration. In addition, the apparent distribution volume is 2.0L/kg, and the bioavailability of a single neck injection is 87%.

[Drug Interaction] (1) Do not use flunixin meglumine concurrently with other non-steroidal anti-inflammatory drugs, as it can exacerbate gastrointestinal toxicity, such as ulcers and bleeding.

(2) Due to the high binding rate of plasma proteins, when used in combination with other drugs, flunixin meglumine may displace other drugs that bind to plasma proteins or be replaced by other drugs, resulting in enhanced effects and even toxicity of the displaced drugs.

(3) It is used in conjunction with antibiotics for the adjunctive treatment of mastitis-metritis-agalactia syndrome in sows.

[Function and Use] Antipyretic and analgesic anti-inflammatory drug, for the treatment of livestock and small animal fever, inflammatory diseases, muscle pain, and soft tissue pain.

[Dosage and Administration] Intramuscular or intravenous injection: 0.4 ml/time per 10kg of body weight for cattle and pigs; 0.2-0.4 ml/time per 10kg of body weight for dogs and cats, administered for once or twice a day, but not for more than 5 consecutive days.

[Adverse Reaction] Intramuscular injection may irritate the local area. Long term high-dose use of this drug may lead to gastric ulcers and kidney function damage in animals.

[Precautions] For livestock with digestive ulcers, this drug should be used with caution.

[Withdrawal Period] 28 days for cattle and pigs.

[Specification] 10ml: 0.5g on the basis of C14H11F3N2O2

[Package] 10ml/pc × 10 pcs/box × 40 boxes/carton

[Storage] It should be kept out of light and tightly sealed for storage.

[Shelf Life] 2 years

[Production License No.] (2022) SYSCZZ No. 08019

[GMP Certificate No.] (2022) SY GMP ZZ No. 08010

[Approval No.] SYZ No. 080192278

[Executive Standard] Volume I of Veterinary Pharmacopoeia of the People’s Republic of China (2020 Edition)