Veterinary Rx
[Veterinary Drug Name]
Generic name: Tilmicosin Injection
Trade name:
English name: Tilmicosin Injection
Pinyin: Timikaoxing Zhusheye
[Main Ingredients] Tilmicosin
[Description] This drug is of light yellow to reddish-brown transparent liquid.
[Pharmacological Action] Pharmacodynamics: Tilmicosin is an animal-specific semi-synthetic macrolide antibiotic. It has a strong effect against Mycoplasma and exhibits antibacterial activity similar to tylosin, with sensitive Gram-positive bacteria including Staphylococcus aureus (including penicillin-resistant Staphylococcus aureus), Streptococcus pneumoniae, Streptococci, Bacillus anthracis, Erysipelothrix rhusiopathiae, Listeria monocytogenes, Clostridium perfringens, and Clostridium chauvoei. Among them, sensitive Gram-negative bacteria include Haemophilus influenzae, Neisseria meningitidis, and Pasteurella species. Its activity against Actinobacillus pleuropneumoniae, Pasteurella, and avian Mycoplasma is stronger than that of tylosin. 95% of Pasteurella haemolytica strains are sensitive to this drug.
Pharmacokinetics: Following subcutaneous injection, absorption is rapid, characterized by strong tissue penetration and a large distribution volume (greater than 2L/kg). High concentrations are found in the lungs and milk, with a half-life of 1 to 2 days, allowing for a prolonged duration of effective blood concentration. When administered to cattle at a dose of 10mg per 1kg of body weight via subcutaneous injection, peak blood concentration is reached within 1 hour, and milk concentrations (greater than 0.8µg/ml) can be maintained for 8 to 9 days. After a single injection, lung tissue can maintain concentrations above the MIC95 (3.12µg/ml) of Pasteurella haemolytica for 3 days. On the third day post-injection, the concentration ratio of tilmicosin in lung to serum is approximately 60:1. Within 0.5 hours after subcutaneous injection, milk concentrations are nearly 50 times higher than blood drug concentrations, with an elimination half-life extending up to 33.8 hours.
[Drug Interaction] (1) The concurrent use of this drug with epinephrine can increase the mortality rate in pigs.
(2) It should not be used concurrently with other macrolides and lincosamides due to the same target sites.
(3) When used with β-lactam antibiotics, it exhibits an antagonistic effect.
[Function and Use] Macrolide antibiotic, for the treatment of infections caused by Actinobacillus pleuropneumoniae, Pasteurella species, and Mycoplasma.
[Dosage and Administration] Subcutaneous injection: 0.033ml per 1kg of body weight for cattle. Only 1 injection is needed.
[Adverse Reaction] The toxic effects of this drug on animals primarily target the cardiovascular system and lead to tachycardia and reduced contractility. Subcutaneous injection in cattle at 50mg/kg can cause myocardial toxicity, while 150mg/kg can be lethal.
[Precautions] (1) Cattle that produce milk for human consumption must not be treated with this drug during the lactation period.
(2) Prohibited for use in beef calves.
(3) Subcutaneous injection may cause local reactions such as edema and it is needed to avoid contact with eyes.
(4) Cardiovascular status should be closely monitored during the administration of this drug.
[Withdrawal Period] 35 days for cattle.
[Specification] 10ml: 3g
[Package] 10ml/pc × 10 pcs/box × 40 boxes/carton
[Storage] It should be kept out of light and tightly sealed for storage.
[Shelf Life] 2 years
[Production License No.] (2022) SYSCZZ No. 08019
[GMP Certificate No.] (2022) SY GMP ZZ No. 08010
[Approval No.] SYZ No. 080192192
[Executive Standard] Volume I of Veterinary Pharmacopoeia of the People’s Republic of China (2020 Edition)
