Veterinary Rx

[Veterinary Drug Name]

Generic name: Erythromycin Thiocyanate Soluble Powder

Trade name: Yidaqing

English name: Erythromycin Thiocyanate Soluble Powder

Pinyin: Liuqingsuan Hongmeisu Kerongxingfen

[Main Ingredients] Erythromycin

[Description] This drug is of white or off-white powder.

[Pharmacological Action] Pharmacodynamics: Erythromycin is a macrolide antibiotic. Its antibacterial action against Gram-positive bacteria is similar to that of penicillin, but its spectrum of activity is broader. Sensitive Gram-positive bacteria include Staphylococcus aureus (including penicillin-resistant strains), Streptococcus pneumoniae, Streptococcus, Bacillus anthracis, Bacillus erysipelatos-suis, Listeria monocytogenes, Clostridium septicum, Clostridium chauvoei, and others. Sensitive Gram-negative bacteria include Haemophilus influenzae, Neisseria meningitidis, Brucella, and Pasteurella. In addition, erythromycin is effective against Campylobacter, Mycoplasma, Chlamydia, Rickettsia, and Leptospira. The antibacterial activity of Erythromycin thiocyanate is enhanced in alkaline solutions; as the pH increases from 5.5 to 8.5, the antibacterial activity gradually increases.

Pharmacokinetics: Erythromycin base and stearate are both easily degraded by gastric acid when taken orally. The type of erythromycin salt, dosage form, acidity of the gastrointestinal tract, and the presence of food in the stomach all affect its bioavailability. Only enteric-coated formulations are well absorbed. After absorption, this drug is widely distributed throughout body tissues and fluids, but it rarely enters cerebrospinal fluid. The plasma protein binding rate is 73%–81%. A small portion of erythromycin is metabolized in the liver to the inactive N-methyl erythromycin. The prototype drug is primarily excreted unchanged in the bile, with only 2%–5% of the dose excreted unchanged in the urine.

[Drug Interaction] (1) This drug should not be used simultaneously with other macrolides or lincosamides, as they share the same target site.

(2) When used in combination with β-lactams, it shows an antagonistic action.

(3) It has an inhibitory effect on the cytochrome oxidase system, and when used with certain drugs, it may inhibit their metabolism.

[Function and Use] Macrolide antibiotic, for the treatment of infectious diseases in chickens caused by Gram-positive bacteria and Mycoplasma, such as staphylococcal infections, streptococcal infections, chronic respiratory disease, and infectious coryza.

[Dosage and Administration] On the basis of this drug. Mixed drinking: 2.5g per 1L of water for chickens, administered for 3-5 consecutive days.

[Adverse Reaction] After oral administration in animals, dose-dependent gastrointestinal disturbances, such as diarrhea, are commonly observed.

[Precautions] (1) Chickens laying eggs for human consumption should not be treated with this drug during the laying period.

(2) This drug should not be combined with acidic substances.

[Withdrawal Period] 3 days for chickens.

[Specification] 100g: 5g (5,000,000 units)

[Package] 100g/packet × 10 packets/ box × 8 boxes /carton

[Storage] It should be sealed and kept in a dry place.

[Shelf Life] 2 years

[Production License No.] (2022) SYSCZZ No. 08019

[GMP Certificate No.] (2022) SY GMP ZZ No. 08010

[Approval No.] SYZ No. 080191492

[Executive Standard] Volume I of Veterinary Pharmacopoeia of the People’s Republic of China (2020 Edition)