Veterinary Rx 

[Veterinary Drug Name]

Generic name: Tilmicosin Premix

Trade name: Kelixin

English name: Tilmicosin Premix

Pinyin: Timikaoxing Yuhunji

[Main Ingredients] Tilmicosin

[Description] This drug is of white or off-white powder or granules.

[Pharmacological Action] Pharmacodynamics: Tilmicosin is an animal-specific semi-synthetic macrolide antibiotic. It has a strong effect against Mycoplasma and exhibits antibacterial activity similar to tylosin, with sensitive Gram-positive bacteria including Staphylococcus aureus (including penicillin-resistant Staphylococcus aureus), Streptococcus pneumoniae, Streptococci, Bacillus anthracis, Erysipelothrix rhusiopathiae, Listeria monocytogenes, Clostridium perfringens, and Clostridium chauvoei. Among them, sensitive Gram-negative bacteria include Haemophilus influenzae, Neisseria meningitidis, and Pasteurella species. Its activity against Actinobacillus pleuropneumoniae, Pasteurella, and avian Mycoplasma is stronger than that of tylosin. 95% of Pasteurella haemolytica strains are sensitive to this drug.

Pharmacokinetics: After oral administration, this drug is rapidly absorbed and characterized by strong tissue penetration and a large volume of distribution (greater than 2 L/kg). It achieves high concentrations in the lungs, with an elimination half-life of 1–2 days, and maintains effective blood drug concentrations for an extended period.

[Drug Interaction] (1) The concurrent use of this drug with epinephrine can increase the mortality rate in pigs.

 (2) It should not be used concurrently with other macrolides and lincosamides due to the same target sites.

(3) When used with β-lactam antibiotics, it exhibits an antagonistic effect.

[Function and Use] Macrolide antibiotic, for the treatment of infections caused by Actinobacillus pleuropneumoniae, Pasteurella species, and Mycoplasma.

[Dosage and Administration] On the basis of this drug. Mixed feeding: per 1000kg of fodders, 1000-2000g for pigs, administered for 15 consecutive days.

[Adverse Reaction] (1) The toxic effects of this drug on animals primarily target the cardiovascular system and lead to tachycardia and reduced contractility.

(2) After oral administration in animals, dose-dependent gastrointestinal disturbances, such as vomiting, diarrhea, and abdominal pain, are commonly observed.

[Precautions] Tilmicosin is irritating to the eyes and may cause allergic reactions. Direct contact should be avoided.

[Withdrawal Period] 14 days for pigs.

[Specification] 20%

[Package] 100g/packet × 10 packets/box × 8 boxes/carton

[Storage] It should be kept out of light and tightly sealed for storage.

[Shelf Life] 2 years

[Production License No.] (2022) SYSCZZ No. 08019

[GMP Certificate No.] (2022) SY GMP ZZ No. 08010

[Approval No.] SYZ No. 080192193

[Executive Standard] Volume I of Veterinary Pharmacopoeia of the People’s Republic of China (2020 Edition)